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Different flavonoids show opposite effects on melanin synthesis, and this is mainly dependent on the chemical structure of the flavonoids, including possessing only hydroxyl groups at the 4′ position of the flavonoid skeleton ring B [72], 4′- O -methylated flavonoids, 3′ and 5′- O -methyl groups [72], which are beneficial in promoting pigmentary hair regeneration

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Anergy Functional impairment of B or T cells resulting from prolonged signalling, usually caused by self-recognition